He hails from Mbaitoli, Imo State, Nigeria. Iheme grew up in Abia State and has a Bachelor of Science in Computer Science from Lagos State University.
Early in his career, Osita Iheme was often typecast in the role of a child. In 2003 he rose to fame when he starred together with Chinedu Ikedieze in the comedy film Aki na Ukwa in which he played the role of Pawpaw. In this role, Iheme played a mischievous child. He has played the role of a child in many of his films but later has adopted more mature roles. Subsequently, the duo became, what many consider, one of the funniest Nollywood comedian pairings of all time.
To reward his contribution towards the growth of the Nigerian Film Industry, in 2011 he was awarded the Nigerian National Honour of Member of the Order of the Federal Republic (MFR) by President Goodluck Jonathan. Influence:
His performance alongside fellow little person actor Chinedu Ikedieze in the 2002 film Aki na Ukwa is still widely spoken about and the duo, especially Osita’s character, has been trending through memes since 2019 on Twitter and other social media platforms. This eventually earned him a large global fanbase.